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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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THE EFFECT OF REGULAR EXERCISE ON DEVELOPMENT OF SARCOMA TUMOR AND OXIDATIVE DAMAGE IN MICE LIVER |
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Maria Sasvari1, Albert W. Taylor2 Dezso Gaal3 and Zsolt Radak1 |
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1Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis University Budapest, Hun-gary, 2School of Kinesiology, Faculty of Health Sciences and Department Physiology, Faculty of Medicine and Den-tistry, University of Western Ontario, London, Canada, and 3National Institute of Oncology, Budapest, Hungary |
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© Journal of Sports Science and Medicine (2011) 10, 93 - 96 |
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| ABSTRACT | |||
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exercise has the capability of decreasing the incidence and progress of
certain cancers. Murine sarcoma, (S-180) cells were transplanted to control
(TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which
had the swimming training terminated at the time of transplantation (ETT),
and also to a group of mice that continued to exercise during tumor bearing
(ETC). Continuous exercise decreased the size of tumor by about 50%. The
accumulation of reactive carbonyl groups (RCD), were not significantly different
for any group. The oxidative modification of proteins in the liver of the
animals decreased in the exercise- trained non-tumor bearing group compared
with control or tumor-bearing groups. No significant alteration was detected
in the level of mutant p53. The data indicate that regular exercise retards
the development of sarcoma solid tumors and it seems unlikely that massive
uncompensated oxidative stress takes place in the tumor.
Key words: Exercise, cancer, oxidative stress, DNA damage, reactive carbonyl derivatives. |
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