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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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EFFECT OF PHLEBODIUM DECUMANUM ON THE IMMUNE RESPONSE INDUCED BY TRAINING IN SEDENTARY UNIVERSITY STUDENTS |
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Jose A. Gonzalez-Jurado1  ,
Francisco Pradas2, Edgardo S. Molina3 and Carlos de
Teresa4 |
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1Faculty of Sport, University of Pablo de Olavide, Sevilla, Spain, 2Faculty of Human Sciences and Education, University of Zaragoza, Spain, 3Faculty of Arts and Physical Education, Metropolitan University of Sciences Education, Department of Physical Education, Santiago, Chile, 4Andaluzian Sport Medicine Centre, San Juan de Dios Universitary Hospital, Granada, Spain |
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© Journal of Sports Science and Medicine (2011) 10, 315 - 321 |
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| ABSTRACT | |||
| Exercise training is considered a good model to provoke different
degrees of immune dysfunction affecting physical performance and some physiological
responses related to oxidative stress and low grade inflammation. Phlebodium
decumanum is a polypodiaceae may induce shown immunomodulating effects,
specifically directed to the release of proinflammatory cytokines by macrophages
in response to various stimuli, as reported different in vitro studies.
The aim of this study was to evaluate the modulating effect of phlebodium
decumanum, on the immune response induced by physical exercise. Thirty-one
subjects (males only) were randomly divided into two groups: Group PD (n
= 18); age: 22.1 ± 1.81, weight 74.21 ± 8.74 kg) that was treated with phlebodium
decumanum; Group P (n = 13); age: 22.5 ± 1.63, weight 78 ± 12.5 kg) that
was treated with a placebo. Before and after one month training program
performed by both groups (three times a week), the following performance
parameters and immune response variables were measured: Dynamic Maximum
Force; Interval-Training; Tennis test; pro-inflammatory (TNF , IL6) and
anti-inflammatory (TNFα-IIrs, IL1-ra) cytokines levels. Data were statistically
analyzed with Mann- Whitney U test and Wilcoxon paired test (p < 0.05).
Statistically significant differences were recorded within groups before
and after the training program. PD group showed a significant improvement
in the performance parameters (Strength Muscle Test: dorsal: p < 0.002;
deltoids: p < 0.03; and pectorals: p < 0.07; Interval Training: p
< 0.06; Tennis Test: p < 0.02). Cytokine levels resulted in a more
positive profile in the PD group rather than in the P group, in which higher
levels of IL-6 (p < 0.02) and a reduction of TNF-IIrs (p < 0.003)
and IL1-ra (p < 0.03) were recorded. In this study the use of phlebodium
decumanum demonstrated beneficial effects in the modulation of the immune
response during physical performance. Key words: Physical exercise, inmunomodulation, TNFα, IL6, TNF-IIrs, IL1-ra. |
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