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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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ACTN3 R577X POLYMORPHISM AND NEUROMUSCULAR RESPONSE TO RESISTANCE TRAINING |
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Paulo Gentil1  ,
Rinaldo W. Pereira2, Tailce K.M. Leite2 and Martim
Bottaro1 |
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1College of Physical Education, University of Brasilia, Brazil, 2Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brazil |
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© Journal of Sports Science and Medicine (2011) 10, 393 - 399 |
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| ABSTRACT | |||
| The R577X polymorphism at the ACTN3 gene has been associated with
muscle strength, hypertrophy and athletic status. The X allele, which is
associated with the absence of ACTN3 protein is supposed to impair performance
of high force/velocity muscle contractions. The purpose of the present study
was to investigate the association of the R577X polymorphism with the muscle
response to resistance training in young men. One hundred forty one men
performed two resistance training sessions per week for 11 weeks. Participants
were tested for 1RM bench press, knee extensors peak torque, and knee extensors
muscle thickness at baseline and after the training period. Genotyping was
conducted using de DdeI restriction enzyme. Genotype distribution was 34.4%
for RR, 47% for RX and 18.6% for the XX genotype. According to the results,
the R577X polymorphism at the ACTN3 gene is not associated with baseline
muscle strength or with the muscle strength response to resistance training.
However, only carriers of the R allele showed increases in muscle thickness
in response to training. Key words: Muscle strength, muscle hypertrophy, peak torque, genotype, alpha-actinin 3, knee extensor. |
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