| ENDURANCE
TRAINING AND GLUTATHIONE-DEPENDENT ANTIOXIDANT DEFENSE MECHANISM IN
HEART OF THE DIABETIC RATS |
Mustafa
Gül ,
Mustafa Atalay,
and Osmo Hänninen
|
Department of Physiology, University of Kuopio, Finland.
| Received |
|
26 February 2003 |
| Accepted |
|
20
March 2003 |
| Published |
|
01 June 2003 |
©
Journal of Sports Science and Medicine (2003) 2, 52- 61
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Regular physical exercise beneficially influences cardiac antioxidant defenses
in normal rats. The aim of this study was to test whether endurance training
can strengthen glutathione-dependent antioxidant defense mechanism and decrease
lipid peroxidation in heart of the streptozotocin-induced diabetic rats.
Redox status of glutathione in blood of diabetic rats in response to training
and acute exercise was also examined. Eight weeks of treadmill training
increased the endurance in streptozotocin-induced diabetic rats. It did
not affect glutathione level in heart tissue at rest and also after exercise.
On the other hand, endurance training decreased glutathione peroxidase activity
in heart, while glutathione reductase and glutathione S-transferase activities
were not affected either by acute exhaustive exercise or endurance training.
Reduced and oxidized glutathione levels in blood were not affected by either
training or acute exercise. Conjugated dienes levels in heart tissue were
increased by acute exhaustive exercise and also 8 weeks treadmill training.
Longer duration of exhaustion in trained group may have contributed to the
increased conjugated dienes levels in heart after acute exercise. Our results
suggest that endurance type exercise may make heart more susceptible to
oxidative stress. Therefore it may be wise to combine aerobic exercise with
insulin treatment to prevent its adverse effects on antioxidant defense
in heart in patients with diabetes mellitus.
KEY WORDS:
Streptozotocin, experimental diabetes mellitus, glutathione, oxidative stress,
conjugated dienes, heart, blood, rat.
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