| INFLUENCE
OF ACUTE EXERCISE ON OXIDATIVE STRESS IN CHRONIC SMOKERS |
Esma
Sürmen-Gür1  ,
Adnan Erdinc1, Zehra Serdar1 and Hakan Gür2
|
1 Department of Biochemistry, Medical Faculty of Uludag University, Bursa,
TURKEY
2 Department of Sports Medicine, Medical Faculty of Uludag University, Bursa,
TURKEY
| Received |
|
05 June 2003 |
| Accepted |
|
15
July 2003
|
| Published |
|
01 September 2003 |
©
Journal of Sports Science and Medicine (2003) 2, 98-105
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The relative oxidative insult caused by exercise and smoking on biological
systems are well documented, however, their cumulative influence needs to
be clarified. In order to examine the collective effects of exercise and
smoking on oxidant and antioxidant parameters, young male smokers (n=10)
and non-smokers (n=10) made to perform a negative slope (10%) cycling exercise
for 30 minutes at individual load equivalent to 60% maximal oxygen consumption
(VO2max). Pre- and post-exercise (post-ex) haematocrit, haemoglobin, white
blood cells, plasma malondialdehyde (MDA) levels, protein carbonyl formation
and non-HDL oxidation, erythrocyte superoxide dismutase (SOD) and glutathione
peroxidase (GPX) activities, serum ceruloplasmin (CER) and urinary cotinine
concentrations were evaluated. Pre-ex CER and urinary cotinine concentrations
of smokers were significantly higher (p<0.05 and p<0.01, respectively) compared
to that of non-smokers and pre-ex CER concentrations were significantly
correlated with cotinine levels in all subjects (p<0.05). Significant (p<0.01)
increases were observed in non-HDL oxidation following the exercise in both
groups and the elevations were more pronounced in smokers. Pre-ex SOD and
GPX activities were not different between the two groups, however post-ex
enzyme activities were significantly reduced in smokers (p<0.05). MDA and
protein carbonyl concentrations were not different between the two groups
and there were not any significant changes due to exercise.In conclusion,
according to the results of the present study, we suggest that erythrocyte
antioxidants SOD and GPX and plasma non-HDL are more prone to the possible
oxidant damage of acute physical exercise in chronic smokers.
KEY WORDS: Exercise, smoking, protein oxidation, non-HDL oxidation,
superoxide dismutase, glutathione peroxidase
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