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EFFECT OF CAFFEINE ON OXIDATIVE STRESS DURING MAXIMUM INCREMENTAL
EXERCISE
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Guillermo
J. Olcina1 ,
Diego Muñoz2, Rafael Timón1, M. Jesús Caballero3,
Juan I. Maynar4, Alfredo Córdova5 and Marcos
Maynar2 |
1Department of Didactics of Music, Plastic and Corporal Expression,
Sport Science Faculty, University of Extremadura, Cáceres, Spain
2Department of Physiology, Sports Sciences Faculty, University of Extremadura,
Cáceres, Spain
3Department of Pharmacology, Faculty of Medicine, University of Extremadura,
Badajoz, Spain
4Department of Analytical Chemistry and Electrochemistry, Sciences Faculty,
University de Extremadura. Badajoz, Spain
5Department of Physiology. School of Physiotherapy. University of Valladolid.
Soria, Spain.
| Received |
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11 April 2006 |
| Accepted |
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02
October 2006 |
| Published |
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15
December 2006 |
©
Journal of Sports Science and Medicine (2006) 5, 621 - 628
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| ABSTRACT |
| Caffeine
(1,3,7-trimethylxanthine) is an habitual substance present in a wide
variety of beverages and in chocolate-based foods and it is also used
as adjuvant in some drugs. The antioxidant ability of caffeine has
been reported in contrast with its pro- oxidant effects derived from
its action mechanism such as the systemic release of catecholamines.
The aim of this work was to evaluate the effect of caffeine on exercise
oxidative stress, measuring plasma vitamins A, E, C and malonaldehyde
(MDA) as markers of non enzymatic antioxidant status and lipid peroxidation
respectively. Twenty young males participated in a double blind (caffeine
5mg·kg- 1 body weight or placebo) cycling test until exhaustion. In
the exercise test, where caffeine was ingested prior to the test,
exercise time to exhaustion, maximum heart rate, and oxygen uptake
significantly increased, whereas respiratory exchange ratio (RER)
decreased. Vitamins A and E decreased with exercise and vitamin C
and MDA increased after both the caffeine and placebo tests but, regarding
these particular variables, there were no significant differences
between the two test conditions. The results obtained support the
conclusion that this dose of caffeine enhances the ergospirometric
response to cycling and has no effect on lipid peroxidation or on
the antioxidant vitamins A, E and C.
KEY
WORDS: Trimethylxanthine, malonaldehyde, vitamins, catecholamines,
VO2 max.
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