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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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EFFECTS OF VOLUNTARY WHEEL RUNNING ON SATELLITE CELLS IN THE RAT PLANTARIS MUSCLE |
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Mitsutoshi Kurosaka1, Hisashi Naito1  ,
Yuji Ogura1,2, Atsushi Kojima2, Katsumasa Goto2,3 and Shizuo Katamoto1 |
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1Department of Exercise Physiology, Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan, 2Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Japan, 3Laboratory of Physiology, Toyohashi SOZO University, Toyohashi, Japan. |
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© Journal of Sports Science and Medicine (2009) 8, 51 - 57 Search Google Scholar for Citing Articles |
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| ABSTRACT | |||
| This study investigated the effects of voluntary wheel running
on satellite cells in the rat plantaris muscle. Seventeen 5-week-old male
Wistar rats were assigned to a control (n = 5) or training (n = 12) group.
Each rat in the training group ran voluntarily in a running-wheel cage for
8 weeks. After the training period, the animals were anesthetized, and the
plantaris muscles were removed, weighed, and analyzed immunohistochemically
and biochemically. Although there were no significant differences in muscle
weight or fiber area between the groups, the numbers of satellite cells
and myonuclei per muscle fiber, percentage of satellite cells, and citrate
synthase activity were significantly higher in the training group compared
with the control group (p < 0.05). The percentage of satellite cells
was also positively correlated with distance run in the training group (r
= 0.61, p < 0.05). Voluntary running can induce an increase in the number
of satellite cells without changing the mean fiber area in the rat plantaris
muscle; this increase in satellite cell content is a function of distance
run.
Key words: Endurance training, muscle damage, hypertrophy, myonuclear, Pax7. |
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