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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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EFFECTS OF ACUTE MODERATE AND STRENUOUS EXERCISE BOUTS ON IL-17 PRODUCTION AND INFLAMMATORY RESPONSE IN TRAINED RATS |
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Halil Duzova  ,
Yunus Karakoc, Memet Hanifi Emre, Zumrut Yilmaz Dogan and Evren Kilinc |
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Department of Physiology, Inonu University Faculty of Medicine, 44280 Malatya, Turkey. |
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© Journal of Sports Science and Medicine (2009) 8, 219 - 224 Search Google Scholar for Citing Articles |
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| ABSTRACT | |||
| In this study, we aimed to compare the effects of a single bout
of acute moderate and strenuous running exercise on the production of interleukin-17
(IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra)
and inflammatory response of skeletal muscles in regularly trained rats.
Eight week old rats were trained by treadmill running 5 days per week for
13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two
days after the last training session, the animals were subjected to a single
bout of moderate or strenuous exercise and serum samples were analyzed for
IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius
muscle were determined. IL-17 level significantly increased in strenuous
exercise group when compared to that of sedentary controls (p < 0.01),
On the other hand, only in the moderate exercise group, there was a negative
correlation between IL-6 and IL-17 levels (r = - 0.857 and p = 0.014). In
conclusion, acute single bout of strenuous exercise increased IL-17 production
in trained rats and, this cytokine may be involved in inflammatory process
of skeletal muscles.
Key words: Interleukin-17, cytokines, running, exercise, rat. |
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