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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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COMPARISON OF LACTATE THRESHOLD, GLUCOSE, AND INSULIN LEVELS BETWEEN OLETF AND LETO RATS AFTER ALL-OUT EXERCISE |
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Hyukki Chang1, Jae-Young Park1, Min-Hwa Suk1, Ho-Jun Lee1, Hyun-Joo Kang2, Kyung-Mook Choi3 and Wook Song1  |
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1Institute of Sports Science, Health and Exercise Science Laboratory, Seoul National University, Korea, 2Department of Sports Medicine, College of Natural Sciences, Soonchunhyang University, Korea, 3Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Korea University, Korea |
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© Journal of Sports Science and Medicine (2009) 8, 381 - 387 |
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| ABSTRACT | |||
| Otsuka Long-Evans Tokushima Fatty (OLETF) rats are an animal model
for obesity and Non Insulin Dependent Diabetes Mellitus by hyperphagia.
The lactate threshold (LT) is used to determinate aerobic capacity and exercise
intensity in individuals. The purpose of this study was to determine whether
velocity at the LT (VLT), glucose, and insulin levels of OLETF
differs from Long-Evans Tokushima (LETO) rats after all-out exercise on
treadmill running. In the results, we found that VLT level of
OLETF rats (17.8 ± 1.39 m·min-1) was significantly lower than
that of the LETO rats (20.5 ± 1.33 m·min-1). The blood glucose
levels immediately after all-out exercise increased in OLETF (from 7.23
± 0.36 to 9.38 ± 1.77 mmol·L-1) and decreased in LETO rats (from
6.36 ± 0.27 to 4.42 ± 0.71 mmol·L-1), and the insulin level was
decreased in both the OLETF (from 34.4 ± 7.7 to 20.13 ± 8.63 µU·mL-1)
and LETO (from 15.29 ± 2.6 to 5.72 ± 1.49 µU·mL-1) rats immediately
after the all-out exercise, but the difference was not significant. Our
results suggest that the different VLT, blood glucose and insulin
levels should be considered to compensate for the differences between the
OLETF and LETO rats. Moreover, the VLT will be a useful reference
for the future studies on exercise training of OLETF rats.
Key words: NIDDM; OLETF, treadmill running, all-out exercise, lactate, velocity of lactate threshold.
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