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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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THE EFFECTS OF REGULAR AEROBIC EXERCISE ON RENAL FUNCTIONS IN STREPTOZOTOCIN INDUCED DIABETIC RATS |
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Hatice Kurdak1  ,
Sunay Sandıkçı2, Nilay Ergen3, Ayşe Dogan3
and Sanlı Sadi Kurdak3 |
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1Department of Family Medicine, Numune Education and Research Hospital, Adana, Turkey, 2Department of Internal Medicine, Numune Education and Research Hospital, Adana, Turkey, 3Department of Physiology, Faculty of Medicine, University of Çukurova, Adana, Turkey |
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© Journal of Sports Science and Medicine (2010) 9, 294 - 299 |
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| ABSTRACT | |||
| Diabetic nephropathy is a feared complication of diabetes since
it can lead to end-stage renal failure and also it is a risk factor of cardiovascular
disease. The important clinical problems caused by diabetic nephropathy
are proteinuria and decreased renal function. Exercise is a cornerstone
of diabetes management, along with diet and medication. Since acute exercise
causes proteinuria and decreases glomerular filtration rate, the effect
of exercise on diabetic nephropathy is controversial. The aim of this study
was to investigate the effect of regular aerobic exercise on microalbuminuria
and glomerular filtration rate in diabetic rats. Moderate diabetes was induced
by streptozotocin (45 mg/kg IV) in rats and an aerobic exercise- training
program on a treadmill was carried out for 8 weeks. Four groups of rats;
control sedentary (CS), control exercise (CE), diabetic sedentary (DS) and
diabetic exercise (DE) were included in the study. Blood glucose levels
were determined from the plasma samples taken at the end of 4 weeks of stabilization
period and 8 weeks of training program. Creatinine clearance (CCr) and microalbuminuria
(MA) levels were determined to evaluate renal functions. The analyzed data
revealed that regular aerobic exercise: 1) significantly decreased the plasma
glucose level of the DE group compared to the DS group (p < 0.05), 2)
significantly decreased the microalbuminuria level of the DE group compared
to those of DS group (p < 0.01), 3) significantly decreased the creatinine
clearance levels of the DE and CE groups compared to those of CS group (p
< 0.05). The results of this study suggest that despite of decreasing
creatinine clearance, regular submaximal aerobic exercise has a preventive
effect on development of microalbuminuria and thus may retard nephropathy
in diabetic rats.
Key words: Aerobic exercise, microalbuminuria, nephropathy, diabetes mellitus. |
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