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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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ASSOCIATION OF CARDIORESPIRATORY FITNESS WITH ELEVATED HEPATIC ENZYME AND LIVER FAT IN JAPANESE PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AND TYPE 2 DIABETES MELLITUS |
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Mayumi Nagano1, Haruka Sasaki2 and Shuzo Kumagai2,3  |
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1Department of Clinical Psychology, Kyoto Bunkyo University, Kyoto, Japan, 2Institute of Health Science, Kyushu University, Fukuoka, Japan, 3Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan. |
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© Journal of Sports Science and Medicine (2010) 9, 405 - 410 |
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| ABSTRACT | |||
| No study has so far determined whether a favorable level of cardiorespiratory
fitness (CF) contributes to a reduced risk of elevated hepatic enzymes and
a high degree of liver fat in patients having various metabolic risks. This
study investigated the association between the maximal oxygen uptake (VO2
max) and the prevalence of elevated liver enzymes and high liver fat, while
considering such factors as abdominal obesity, hyperinsulinemia and the
other metabolic risks. The study enrolled newly diagnosed Japanese patients
(n = 84; 52 males and 32 females; aged 25-69 years) with impaired glucose
tolerance (IGT) and type 2 diabetes mellitus (Type2DM) who did not receive
any intervention or pharmacological therapy. The subjects were divided into
3 groups according to the distribution of the VO2max for each
sex. The odds ratios (ORs) for the prevalence of elevated aspartate and
alanine aminotransferase (AST and ALT) and high degree of liver fat adjusted
for age, sex, disease type, daily ethanol intake, and current smoking were
significantly lower in the moderate- and high CF groups in comparison to
the low CF group. In addition, a significant OR for AST was maintained in
the moderate and high CF group after adjusting for abdominal obesity and/or
hyperinsulinemia. The significant ORs for the prevalence of elevated ALT
and a high degree of liver fat were attenuated after adjusting for abdominal
obesity and/or hyperinsulinemia. No significant OR for the prevalence of
elevated gamma-glutamyl transferase (GGT) was recognized in all logistic
models. These results indicated that CF was negatively and independently
associated with the prevalence of elevated AST even in Japanese diabetic
patients having various metabolic risks. It was concluded that the AST level
might be useful as a simple marker reflecting physical inactivity in such
subjects.
Key words: Cardiorespiratory fitness, hepatic enzyme, non-alcoholic fatty liver, abdominal obesity, insulin resistance. |
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