**Figure 1.** Total exercise time tolerated by the subjects with lower (A) and higher (B) aerobic capacity during cycling at 60% of their maximal power output. Each subject participated in four experimental trials with the following drug conditions: placebo and 10, 20 and 40 mg of paroxetine. The data are expressed as the mean ± SEM. * denotes significant differences relative to the respective control trial in the subjects with lower aerobic capacity (p < 0.05). # denotes a significant difference relative to the placebo trial (p < 0.05).