Figure 3. Internal body temperature recorded at rest, at 2-min intervals during exercise and at the voluntary termination of exercise by subjects with lower (A) and higher (B) aerobic capacity. During exercise, the internal temperature is presented until the 20 min, which represents the last time point at which all subjects were still cycling. The panels C and D show the cycling exercise-induced heat storage rate recorded in the subjects with lower and higher aerobic capacity, respectively. Each subject participated in four experimental trials with the following drug conditions: placebo and 10, 20 and 40 mg of paroxetine. The data are expressed as the mean ┬▒SEM. 1 denotes that the results in the 40 mg paroxetine trial were significantly different from the results in the 10 mg paroxetine trial (p < 0.05). 2 denotes that the results in the 40 mg paroxetine trial were significantly different from the results in the placebo trial (p < 0.05). * denotes significant differences relative to the respective control trial in subjects with lower aerobic capacity (p < 0.05).