**Figure 2.** The score plot of OPLS analysis to compare the metabolome of male and female rats from control, exhaustive exercise and recovery groups (n=10 per group). A: The score plot showed distinct clustering of metabolites with gender and exhaustive exercise periods. Metabolic patterns were grouped by different colored points. One point represents one sample. B: The loading plot was created to display the specific metabolites positively correlated with score plot. Each point presents one variable (metabolite). The bigger red triangle () indicates statistically significant difference in variables that differentiated these groups. S-d10: 10-day swimming (exhaustive exercise group); R-d7: 7-day recovery.