Figure 3. OPLS score plots of male rats (A) and female rats (B) over the whole exercise program (n=10). Both for the male and female rats, clear movement of data points along with exhaustive exercise period and recovery period was shown, indicating that exhaustive exercise had significant impact on plasma metabolome, and that one-week recovery could attenuate the exhaustive exercise induced metabolic perturbation in rats. Metabolic patterns were grouped by different colored points, one point represents one sample. ■/Control, control group; /S-d5, 5 days swimming; /S-d10, 10-day swimming; /R-d3, 3 days recovery; /R-d7, 7-day recovery.