Table 3. Gender-specific association of the CTI with dyslipidemia incidence.
| Sex |
Variable |
Number
of events, n |
Model
1 |
Model
2 |
Model
3 |
| HR |
95%
CI |
p |
HR |
95%
CI |
p |
HR |
95%
CI |
p |
| Male |
CTI
(per 1-unit) |
785 |
1.21 |
1.06-1.37 |
0.01 |
1.19 |
1.05-1.35 |
0.01 |
1.18 |
1.04-1.35 |
0.01 |
| Q1
(Ref) |
148 |
|
|
|
|
|
|
|
|
|
| Q2 |
178 |
1.07 |
0.86-1.33 |
0.53 |
1.05 |
0.85-1.31 |
0.65 |
1.00 |
0.83-1.31 |
0.51 |
| Q3 |
214 |
0.98 |
0.80-1.21 |
0.85 |
0.95 |
0.77-1.17 |
0.62 |
0.94 |
0.77-1.16 |
0.72 |
| Q4 |
245 |
1.28 |
1.04-1.57 |
0.02 |
1.24 |
1.01-1.53 |
0.04 |
1.25 |
1.04-1.56 |
0.03 |
| P
for trend |
|
|
|
0.04 |
|
|
0.07 |
|
|
0.05 |
| Female |
CTI
(per 1-unit) |
1226 |
1.04 |
0.95-1.14 |
0.41 |
1.04 |
0.95-1.14 |
0.40 |
1.01 |
0.92-1.12 |
0.56 |
| Q1
(Ref) |
232 |
|
|
|
|
|
|
|
|
|
| Q2 |
270 |
0.98 |
0.83-1.17 |
0.86 |
0.98 |
0.82-1.17 |
0.81 |
0.96 |
0.81-1.14 |
0.77 |
| Q3 |
328 |
1.13 |
0.95-1.33 |
0.16 |
1.11 |
0.93-1.31 |
0.24 |
1.08 |
0.92-1.28 |
0.29 |
| Q4 |
396 |
1.09 |
0.93-1.28 |
0.31 |
1.09 |
0.92-1.28 |
0.33 |
1.06 |
0.90-1.24 |
0.40 |
| P
for trend |
|
|
|
0.15 |
|
|
0.16 |
|
|
0.22 |
HR = hazard ratio; CI = confidence interval. Q1 denotes the lowest quartile, used as the reference category. Model 1 included no covariate adjustment; Model 2 was adjusted for demographic and lifestyle factors (age, residence, marital status, education, smoking, and alcohol consumption); and Model 3 additionally accounted for comorbid conditions such as chronic diseases, arthritis, liver disease, asthma, kidney disease, and gastrointestinal disorders, as well as the use of anti-diabetic medication, anti-hypertensive medication, and lipid-lowering medication as covariates. The p for trend was estimated by modeling the median value of each quartile as a continuous variable in the Cox regression model.
