Table 4. Age-specific association of the CTI with incident dyslipidemia
| Age
group |
Variable |
Number
of events, n |
Model
1 |
Model
2 |
Model
3 |
| HR |
95%
CI |
p |
HR |
95%
CI |
p |
HR |
95%
CI |
p |
| 45-59 |
CTI
(per 1-unit) |
1229 |
1.25 |
1.10-1.42 |
0.01 |
1.23 |
1.09-1.40 |
0.01 |
1.21 |
1.06-1.37 |
0.01 |
| Q1
(Ref) |
220 |
|
|
|
|
|
|
|
|
|
| Q2 |
280 |
1.05 |
0.85-1.30 |
0.65 |
1.04 |
0.84-1.28 |
0.70 |
1.02 |
0.81-1.25 |
0.71 |
| Q3 |
320 |
1.12 |
0.90-1.39 |
0.32 |
1.10 |
0.88-1.37 |
0.38 |
1.07 |
0.85-1.34 |
0.40 |
| Q4 |
409 |
1.40 |
1.12-1.75 |
0.01 |
1.38 |
1.11-1.73 |
0.01 |
1.35 |
1.11-1.72 |
0.01 |
| P
for trend |
|
|
|
0.01 |
|
|
0.01 |
|
|
0.01 |
| ≥60 |
CTI
(per 1-unit) |
782 |
1.15 |
1.02-1.31 |
0.02 |
1.14 |
1.01-1.29 |
0.03 |
1.12 |
1.01-1.27 |
0.04 |
| Q1
(Ref) |
180 |
|
|
|
|
|
|
|
|
|
| Q2 |
190 |
1.08 |
0.86-1.36 |
0.52 |
1.07 |
0.85-1.34 |
0.56 |
1.04 |
0.83-1.32 |
0.57 |
| Q3 |
200 |
1.15 |
0.92-1.45 |
0.23 |
1.14 |
0.91-1.43 |
0.25 |
1.11 |
0.91-1.41 |
0.26 |
| Q4 |
212 |
1.32 |
1.05-1.66 |
0.02 |
1.30 |
1.03-1.63 |
0.03 |
1.26 |
1.00-1.62 |
0.04 |
| P
for trend |
|
|
|
0.02 |
|
|
0.03 |
|
|
0.04 |
HR = hazard ratio; CI = confidence interval. Q1 denotes the lowest quartile, which served as the reference category. Model 1 included no covariate adjustment; Model 2 was adjusted for demographic and lifestyle factors (sex, residence, marital status, education, smoking, and alcohol consumption); and Model 3 additionally accounted for comorbid conditions such as chronic diseases, arthritis, liver disease, asthma, kidney disease, and gastrointestinal disorders, as well as the use of anti-diabetic medication, anti-hypertensive medication, and lipid-lowering medication as covariates. The p for trend was estimated by modeling the median value of each quartile as a continuous variable in the Cox regression model. Statistical significance was defined as a two-sided p < 0.05.
