Table 2 List of the 25 genetic markers found to be significant different between the SF and the C groups, hence associated with SF pathogenesis: both SNPs and haplotypes analyses within the following 9 genes: .
Gen Genetic marker Data OR (95% CI, p-value) #Model analysis
NR3C1 SNP rs4244032 G/A (A/A) .94(.39-.61, p=.04) CD
G/A (A/A-G/G) .58(.38-.89, p=.01) OD
rs 12656106 G/C (G/G) .57(.36-.91, p=.04) CD
C/C (G/G) .54(.29-.98, p=.04) CD
G/C-C/C (G/G) .56(.36-.87, p=.01) D
Hap. GAAAA 13.74(6.66) 2.11 (1.01-4.39, p=.05) CD
GT 44.12(36.87) 1.49 (1.07-2.07, p=.02) CD
ANKH SNP rs4701616 C/T/-C/C (C/T) 1.67(l.ll-2.53,p = .01) D
VDR SNP rs4328262 G/T(T/T) .57(.33-.99,p=.04) D
G/T (T/T-G/G) .53(.32-.88,p=.01) OD
Hap. ACCTATAAG 2.65 (3.3) .16(.04-.62,p=.01) CD (1st block)
CCAGGCAC 4.2 (NA) 12.22(1.45-102.7, p=.02) CD (2nd block)
R0R2 SNP rsl0992075 G/A (A/A) 1.68(1.04-2.69, p = .02) J CD
Hap. CCCTACC 6.97(4.45) 2.71 (1.03-7.12, p = .04) CD (block 5a)
CALCR SNP rsl2154667 T/T (C/C) .48(.27-.85, p=.01) CD
C/T (C/C) .47(.29-.77, p=.01) CD
C/T-T/T (C/C) .47(.30-.75, p=.001) D
rsl 548456 T/T (C/C) 2.23 (1.2-4.15, p=.01) CD
T/T (C/C-C/T) 2.39(1.35-4.25, p=. 002) R
Hap. CGTTCTCCGA 12.91 (8.43) 1.93 (1.09-3.43, p=.003) CD
CC 16.05(13.75) 1.68 (1.05-2.71, p = .02) J CD
CT 41.25(33.96) 1.47(1.08-2.02, p = .02) CD
IL6 SNP rsl554606 T/T (G/G-G/T) 3.48(1.35-8.94, p=.005) R
C0L1A2 SNP rs420257 C/C (T/T-T/C) 2.29 (1.10-4.80, p = .02) R
rs42517 G/G (A/A-A/G) 11.03(1.36-89.20, p=.003) R
rs42522 G/G (A/A-A/G) 2.21 (1.02-4.77, p = .04) R
rs24531 A/G (G/G) .54(.34-.88,p=.01) CD
rs413826 C/G-G/G (C/C) .53(.32-.88,p=.01) D
CBG SNP rsl 1629171 C/T-T/T (C/C) 1.65(1.09-2.50, p = .02) D
rs2281518 T/C (T/T-C/C) 1.52(1.00-2.32, p = .05) OD
Hap. CATCCT 14.5(9.75) 1.82 (1.03-3.22, p = .04) CD
LRP4 SNP rs2306033 .4/G-A//4 (G/G) .39 (.21-0.72, p =.002) D
Inducer marker / Protective marker (Italic style).
‡ Adjusted for BMI
† SNP analysis- SNPs genotyping using the relevant model: CD- Co dominant model, whereas rare genotype (in comparison to the frequent genotype), e.g., A/T (T/T) = the frequent genotype is T/T; D- Dominant model, whereas both heterozygous and rare homozygous (in comparison to the frequent genotype, the frequent homozygous)side; OD- Over dominant model, whereas heterozygous genotype (in comparison to both homozygous genotypes), e.g., A/C (A/A-C/C); R- Recessive model, whereas rare homozygous (in comparison to both: frequent homozygous and heterozygous genotypes). - Distribution (%) among SF group (in brackets the haplotype frequency among the C group); e.g., 2.65 (3.3) = 2.65% distribution among the SF group in comparison to 3.3% distribution among the C group
# Model analysis: CD=Co dominant SNP analysis; D=Dominant SNP analysis; OD=Over dominant SNP analysis.