Table 6. Analysis of the two-way and three-way interactions between ADRB2, ADRB3 and ADRA2A genes using quantitative multifactor dimensionality reduction for body composition parameters, lipids and glucose.
Variables Best model* Cross-validation training score Cross-validation testing score CVC* p
body mass (kg) Gly16Arg 1.57 0.61 9/10 0.557
BMI (kg/m2) Gly16Arg 2.35 1.06 9/10 0.435
%FM (%) Gly16Arg,G1780A 2.45 -0.75 6/10 0.875
FFM (kg) G1780A 1.18 -2.29 6/10 0.995
TBW (kg) Gly16Arg, Glu27Gln,Trp64Arg 2.20 -1.86 6/10 0.986
TC (mg/dL) Glu27Gln 1.81 1.91 10/10 0.213
TGL (mg/dL) Glu27Gln 2.11 -1.56 6/10 0.969
HDL (mg/dL) Trp64Arg, G1780A 3.69 3.67 10/10 0.018
LDL (mg/dL) Glu27Gln 1.76 0.55 7/10 0.557
Glucose (mg/dL) Gly16Arg,Glu27Gln, Trp64Arg 2.45 -1.25 9/10 0.960
*ablethe best gene-gene interaction model was determined using cross-validation consistency (CVC) and cross-validation testing score
† permuted p value (1000 permutations)