Supplementary Table 4. Threshold-gradient sensitivity analysis using any two consecutive days. Consecutive-two-day threshold Weekend warrior, HR (95% CI); P Regularly active, HR (95% CI); P ≥ 55% 0.868 (0.812, 0.927); < 0.001 0.902 (0.858, 0.949); < 0.001 ≥ 60% 0.878 (0.815, 0.946); < 0.001 0.896 (0.853, 0.941); < 0.001 ≥ 65% 0.840 (0.766, 0.921); < 0.001 0.900 (0.858, 0.944); < 0.001 ≥ 70% 0.863 (0.775, 0.961); 0.007 0.895 (0.854, 0.939); < 0.001 ≥ 75% 0.860 (0.755, 0.980); 0.024 0.894 (0.853, 0.938); < 0.001 ≥ 80% 0.850 (0.723, 1.000); 0.050 0.894 (0.853, 0.937); < 0.001 ≥ 85% 0.762 (0.606, 0.958); 0.020 0.895 (0.854, 0.938); < 0.001 ≥ 90% 0.702 (0.521, 0.945); 0.020 0.895 (0.854, 0.938); < 0.001 ≥ 95% 0.669 (0.421, 1.063); 0.089 0.894 (0.853, 0.937); < 0.001 HRs were estimated using Cox proportional hazards models. At each threshold, the exposure was classified as inactive (<150 min/week of MVPA), consecutive-day WW (>=150 min/week and at least the stated percentage of total weekly MVPA accumulated during any two consecutive days), or regularly active (>=150 min/week and below the stated percentage). Inactive participants were the reference group. The outcome was incident overall OA, defined as the first recorded ICD-10 M15-M19 diagnosis during follow-up among participants without OA at baseline. Models adjusted for age at accelerometer assessment, sex, ethnicity, education, Townsend deprivation index, smoking status, alcohol intake frequency, and BMI. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; ICD-10, International Classification of Diseases, 10th Revision; MVPA, moderate-to-vigorous physical activity; OA, osteoarthritis; WW, weekend warrior.