Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine ( 2004 ) 03 , 15 - 22

Young Investigator Special Issue 1: Research article
Muscular Oxidative Capacity in Ovariectomized Rats Discussion on the Endurance Performance of Female Athletes with Sports-Related-Amenorrhea
Takahiro Sasa1, Koichi Sairyo1, , Naoyuki Yoshida1, Makoto Ishikawa2, Mari Fukunaga2, Natsuo Yasui1
Author Information
1 Department of Orthopedics, The University of Tokushima, Tokushima, Japan
2 Bioenergetics Research Office, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan

Koichi Sairyo
✉ Department of Orthopedics, The University of Tokushima, 3-18-15, Kuramoto, Tokushima 770-8506 Japan
Email: sairyokun@hotmail.com
Publish Date
Received: 25-05-2004
Accepted: 26-07-2004
Published (online): 01-11-2004
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ABSTRACT

The purpose of this study was to evaluate the effects of ovariectomy on intramuscular energy metabolism in adult rats. Based on the results, we discussed the skeletal muscle metabolism in female athlete with sports related amenorrhea. Twenty-five adult (20-week-old) Sprague-Dawley female rats were used. Fifteen rats underwent ovariectomy (OVX group), and the other ten rats were sham-operated (Sham group). One and four weeks after surgery, muscular oxidative capacity was measured using 31P-MR spectra of the gastrocnemius-plantaris-soleus (GPS) muscles group at rest and during electric stimulation. Wet weight and maximum tension of the whole GPS muscles group were also measured. From the MRS measurements, the muscle oxidative capacity in the OVX group was significantly lower than that in the Sham group (p < 0.05) at both one and four weeks after surgery. The muscle’s wet weight one week after surgery in the OVX group was the same as the Sham group, while four weeks after surgery it was significantly greater than that in the Sham group (p < 0.05). There were no significant differences in maximum tension among the groups. In conclusion, in adult rats the oxidative capacity decreased due to ovariectomy despite the increase in muscle weight. It is suggested that the muscular endurance capacity in female adult athletes with sports related amenorrhea may deteriorate.

Key words: Sports-related-amenorrhea, skeletal muscle, oxidative capacity, P-MRS, ovariectomy


           Key Points
  • In vivo measurement of muscular energy metabolism.
  • Effects of ovariectomy on muscle function and volume.
  • Muscle function of sports-related amenorrhea.
 
 
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