Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine ( 2014 ) 13 , 15 - 21

Research article
VEGF and BFGF Expression and Histological Characteristics of the Bone-Tendon Junction during Acute Injury Healing
Lin Wang1, , Weiwei Gao1, Kaiyu Xiong2, Kuan Hu3, Xincun Liu3, Hui He2
Author Information
1 Section of Sports Medicine, Beijing Sport University, Beijing, China
2 Teaching Experiment Center, Beijing Sport University, Beijing, China
3 Graduate College, Beijing Sport University, Beijing, China

Lin Wang
‚úČ Section of Sports Medicine, Beijing Sport University, Beijing, China
Email: waley@bsu.edu.cn
Publish Date
Received: 25-02-2013
Accepted: 20-08-2013
Published (online): 20-01-2014
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ABSTRACT

Bone-tendon junction (BTJ) injuries are common and may be caused by acute trauma and delayed healing during exercise or work. To understand the nature of the healing process of BTJ injuries would help to prevent injuries and improve treatment. Thirty-three mature female rabbit hindlimbs were assigned to normal control (CON, n = 7) and injury groups (n = 26). The acute injury was established by administering one 7 plum-blossom needle puncture. Specimens were harvested post injury at 1, 2, 4, and 8 weeks (ND1W, n = 6; ND2W, n = 6; ND4W, n = 7; and ND8W, n = 7). The injury existed in all of the injury groups. Compared with the CON group, all of the animals in the injury group showed poor cell profiles, an unclear or undetectable tide mark, a proteoglycan area and profile changes; the BTJ cell density diminished significantly in the ND1W (p < 0.01), ND2W (p < 0.05), ND4W (p < 0.01), and ND8W groups (p < 0.01); the fibrocartilage zone thickness in all injury groups was significantly thicker than in the CON group (p < 0.05), but no significant difference was found among the injury groups (p>0.05). The basic fibroblast growth factor (bFGF) expression in the CON group was significantly less than in the ND1W group (p<0.01), but no significant difference was found when compared with the ND2W, ND4W, and ND8W groups. The bFGF expression in the ND1W group was higher than that of the ND4W (p < 0.05) and ND8W groups (p < 0.01). The vascular endothelial growth factor (VEGF) levels were not significantly different among the groups (p > 0.05). The bFGF and VEGF expression levels indicated that the healing process stopped at 8 weeks post injury or was not activated, although the injury had not healed by histological examination. A repeatable animal model of BTJ acute injury was established in this study, and the results described the BTJ acute injury healing difficult concerned with the repairing stop.

Key words: Bone-tendon junction injury, puncture, histology, growth factor


           Key Points
  • This study described the bone-tendon junction acute injury nature healing process.
  • The bone-tendon junction acute injury could not be repaired naturally in 8 weeks.
  • The bFGF and VEGF expression revealed that the bone-tendon junction acute injury delayed healing concern with the repairing stop.
 
 
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