Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2020) 19, 121 - 129

Research article
Changes in Urinary Titin N-terminal Fragment Concentration after Concentric and Eccentric Exercise
Shota Yamaguchi1, , Katsuhiko Suzuki2, Takayuki Inami3, Kazue Kanda4, Zhao Hanye1, Junichi Okada2
Author Information
1 Graduate School of Sport Sciences, Waseda University, Saitama, Japan
2 Faculty of Sport Sciences, Waseda University, Saitama, Japan
3 Institute of Physical Education, Keio University, Yokohama, Kanagawa, Japan
4 Institute for Nanoscience & Nanotechnology, Waseda University, Shinjuku, Tokyo, Japan

Shota Yamaguchi
‚úČ Graduate School of Sport Sciences, Waseda University, Saitama, Japan
Email: y.shota-56@akane.waseda.jp
Publish Date
Received: 29-07-2019
Accepted: 26-11-2019
Published (online): 24-02-2020
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ABSTRACT

We aimed to compare the urinary titin N-terminal fragment (UTF) concentration after concentric and eccentric exercise and to clarify the specific response of UTF to exercise-induced muscle damage (EIMD). Nine healthy young men performed 30 concentric elbow flexion exercises with maximum effort, rested for at least eight weeks, and performed eccentric exercises at the same workload using the same arm. Changes in the maximal voluntary isometric contraction (MVIC), muscle soreness (SOR), range of motion (ROM), serum creatine kinase (CK) activity, and UTF concentrations were recorded before and after for six consecutive days after exercise. There was no significant difference in workload during exercise between the two exercise types. However, serum CK activity increased after eccentric exercise (p < 0.05). Additionally, MVIC, SOR, ROM, and UTF concentration were significantly higher after eccentric exercise than after concentric exercise (p < 0.05). Although workload was the same, the UTF concentration greatly increased after eccentric exercise. Based on these results, we suggest that UTF can be a non-invasive and highly specific biomarker of EIMD.

Key words: Biomarker, exercise-induced muscle damage, delayed onset muscle soreness, validity, non-inversive


           Key Points
  • This study investigated urinary titin N-terminal fragment (UTF) concentration after concentric and eccentric exercise performed at the same workload.
  • Although both exercises were performed at the same workload, UTF concentrations significantly differed between the concentric and eccentric conditions.
  • UTF will be useful as a new biomarker for specific measurement of EIMD because it UTF specifically responded to EIMD after eccentric contraction.
 
 
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