Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2002) 01, 103 - 114

Review article
Exercise-Induced Signal Transduction and Gene Regulation In Skeletal Muscle
Henning Wackerhage , Niall M. Woods
Author Information
Department of Biological Sciences, University of Central Lancashire, Preston, UK

Henning Wackerhage
✉ Department of Biological Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom.
Publish Date
Received: 01-05-2002
Accepted: 10-07-2002
Published (online): 01-12-2002
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Skeletal muscle adapts to various forms of exercise depending on the force, speed and duration characteristics of the contraction pattern. The stresses and signals associated with each contraction pattern are likely to specifically activate a network of signal transduction pathways that integrate this information. These pathways include the calcineurin, Calcium/calmodulin-dependent protein kinase (CaMK), mitogen-activated protein kinase (MAPK), protein kinase C (PKC), nuclear factor kappa B (NF-κB), AMP-dependent protein kinase (AMPK), insulin signalling and developmental pathways. Activated signal transduction pathways activate or increase the expression of transcription factors via various mechanisms. Skeletal muscle genes are usually regulated by combinatorial control exerted by several transcription factors and possibly other mechanisms. In addition, adaptations such as an increase in mitochondrial biogenesis or the activation of satellite cell proliferation involve distinct regulatory mechanisms.

Key words: Adaptation, calcineurin myosin heavy chain, mitochondrial biogenesis, satellite cells

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