Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2003) 02, 52 - 61

Research article
Endurance Training and Glutathione-Dependent Antioxidant Defense Mechanism in Heart of the Diabetic Rats
Mustafa Gül, Mustafa Atalay , Osmo Hänninen
Author Information
Department of Physiology, University of Kuopio, Finland

Mustafa Atalay
✉ Department of Physiology, University of Kuopio, Kuopio, 70211 Kuopio, Finland
Email: mustafagul@hotmail.com
Publish Date
Received: 26-02-2003
Accepted: 20-03-2003
Published (online): 01-06-2003
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ABSTRACT

Regular physical exercise beneficially influences cardiac antioxidant defenses in normal rats. The aim of this study was to test whether endurance training can strengthen glutathione-dependent antioxidant defense mechanism and decrease lipid peroxidation in heart of the streptozotocin-induced diabetic rats. Redox status of glutathione in blood of diabetic rats in response to training and acute exercise was also examined. Eight weeks of treadmill training increased the endurance in streptozotocin-induced diabetic rats. It did not affect glutathione level in heart tissue at rest and also after exercise. On the other hand, endurance training decreased glutathione peroxidase activity in heart, while glutathione reductase and glutathione S-transferase activities were not affected either by acute exhaustive exercise or endurance training. Reduced and oxidized glutathione levels in blood were not affected by either training or acute exercise. Conjugated dienes levels in heart tissue were increased by acute exhaustive exercise and also 8 weeks treadmill training. Longer duration of exhaustion in trained group may have contributed to the increased conjugated dienes levels in heart after acute exercise. Our results suggest that endurance type exercise may make heart more susceptible to oxidative stress. Therefore it may be wise to combine aerobic exercise with insulin treatment to prevent its adverse effects on antioxidant defense in heart in patients with diabetes mellitus.

Key words: Streptozotocin, experimental diabetes mellitus, oxidative stress, conjugated dienes, heart, blood, rat


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