Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2006) 05, 621 - 628

Research article
Effect of Caffeine on Oxidative Stress During Maximum Incremental Exercise
Guillermo J. Olcina1, , Diego Muñoz2, Rafael Timón1, M. Jesús Caballero3, Juan I. Maynar4, Alfredo Córdova5, Marcos Maynar2
Author Information
1 Department of Didactics of Music, Plastic and Corporal Expression, Sport Science Faculty, University of Extremadura, Cáceres, Spain
2 Department of Physiology, Sports Sciences Faculty, University of Extremadura, Cáceres, Spain
3 Department of Pharmacology, Faculty of Medicine, University of Extremadura, Badajoz, Spain
4 Department of Analytical Chemistry and Electrochemistry, Sciences Faculty, University de Extremadura, Badajoz, Spain
5 Department of Physiology. School of Physiotherapy. University of Valladolid, Soria, Spain

Guillermo J. Olcina
✉ Facultad de Ciencias del Deporte. Universidad de Extremadura, Avenida de la Universidad s/n 10071. Cáceres. ESPAÑA
Publish Date
Received: 11-04-2006
Accepted: 02-10-2006
Published (online): 15-12-2006
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Caffeine (1,3,7-trimethylxanthine) is an habitual substance present in a wide variety of beverages and in chocolate-based foods and it is also used as adjuvant in some drugs. The antioxidant ability of caffeine has been reported in contrast with its pro- oxidant effects derived from its action mechanism such as the systemic release of catecholamines. The aim of this work was to evaluate the effect of caffeine on exercise oxidative stress, measuring plasma vitamins A, E, C and malonaldehyde (MDA) as markers of non enzymatic antioxidant status and lipid peroxidation respectively. Twenty young males participated in a double blind (caffeine 5mg·kg- 1 body weight or placebo) cycling test until exhaustion. In the exercise test, where caffeine was ingested prior to the test, exercise time to exhaustion, maximum heart rate, and oxygen uptake significantly increased, whereas respiratory exchange ratio (RER) decreased. Vitamins A and E decreased with exercise and vitamin C and MDA increased after both the caffeine and placebo tests but, regarding these particular variables, there were no significant differences between the two test conditions. The results obtained support the conclusion that this dose of caffeine enhances the ergospirometric response to cycling and has no effect on lipid peroxidation or on the antioxidant vitamins A, E and C.

Key words: Trimethylxanthine, malonaldehyde, vitamins, catecholamines, VO max

           Key Points
  • Caffeine ingestion may improve maximal aerobic performance in non trained men.
  • Cellular oxidative damage is not altered by caffeine ingestion in maximal aerobic exercises.
  • Antioxidant response to exercise, vitamins A, E and C, is not modified by caffeine action in maximal aerobic efforts.
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