Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2007) 06, 220 - 226

Research article
Angiotensin I Converting Enzyme Gene Polymorphism and Exercise Trainability in Elderly Women: An Electrocardiological Approach
Takuro Tobina1,2, , Akira Kiyonaga2, Yuko Akagi3, Yukari Mori3, Kojiro Ishii1, Hitoshi Chiba4, Munehiro Shindo2, Hiroaki Tanaka2
Author Information
1 Graduate School of Education, Hokkaido University,
2 Faculty of Sports and Health Science, Fukuoka University, Fukuoka,
3 Graduate School of Sports and Exercise Science, Fukuoka University,
4 Department of Health Sciences, Hokkaido University School of Medicine, Japan

Takuro Tobina
‚úČ Kita 11 jo nishi 7 Kita-ku, Sapporo City, Hokkaido, JAPAN 060-0811.
Publish Date
Received: 06-11-2006
Accepted: 28-02-2007
Published (online): 01-06-2007
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Angiotensin I converting enzyme (ACE) gene Insertion / Deletion (I/D) polymorphism is associated with exercise trainability and exercise induced left ventricular hypertrophy. However, it is unclear whether this polymorphism influences exercise trainability in the elderly, and the electrocardiological alterations by exercise training is unknown among the genotypes. We herein investigated the association between ACE gene insertion/deletion (I/D) polymorphism, exercise trainability and the electrocardiological alternations by exercise in elderly women. Eighty four elderly women participated in this study. In all subjects the leg extension power (LEP) and lactate threshold (LT) were determined in order to evaluate the muscle strength, aerobic capacity and to also select the appropriate training intensity for each individual. They performed bench step exercise training for 12 weeks. A resting electrocardiogram was recorded for the obtained QTc interval in before and after the program. The baseline of aerobic capacity was higher in I/I than that in I/D, and the QTc interval was shorter in I/I than that in I/D. All other characteristics were similar among the genotypes. The QTc interval tended to be shorten only in the D/D. Furthermore, the value of the QTc interval change showed a significant difference between the I/I and D/D genotype after the program. The LT and LEP demonstrated a similar response among the genotypes. The D allele of ACE gene I/D polymorphism may therefore play a role in the electrocardiological aspect during exercise training, however, it was not found to influence the aerobic capacity.

Key words: Electrophysiology, exercise, genes

           Key Points
  • The D allele of ACE gene I/D polymorphism may play a role in the electrocardiological aspects during exercise training
  • ACE gene I/D polymorphism was not determined the aerobic capacity and leg strength in elderly people.
  • The ACE gene I/D polymorphism did not influence aerobic and strength trainability in elderly people.
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