Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2007) 06, 227 - 232

Research article
IGF-I and FGF-2 Responses to Wingate Anaerobic Test in Older Men
Ruthie Amir , David Ben-Sira, Moran Sagiv
Author Information
Sports Medicine & Rehabilitation Division, Zinman College of Physical Education and Sport Sciences, Wingate, Israel

Ruthie Amir
✉ Director, Genetics and Molecular Biology, Zinman College, Wingate, 42902, Israel
Email: ruthiea@wincol.ac.il
Publish Date
Received: 16-10-2006
Accepted: 07-03-2007
Published (online): 01-06-2007
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ABSTRACT

Reduced activity of the potent anabolic effectors: insulin-like growth factor-I (IGF-I) and fibroblast growth factor-2 (FGF-2), play a role in aging associated muscle loss. The effect of fitness level on IGF-I and FGF-2 responses to all-out anaerobic exercise in older men was studied. Twenty four healthy older males: 12 higher fit (58 ± 1y) and 12 lower fit (59 ± 1y) underwent the Wingate anaerobic test. Serum levels of IGF-I and FGF-2 were measured before, immediately after exercise, and 50 min into recovery. Immediately post exercise, the average peak power output and serum lactate were higher (p < 0.05) in the higher fit (446.0 ± 14. 9 kgm·min-1 for mean (± SD) peak power and 12.6 ± 1.1 mml·l-1 for lactate) compared with the lower fit individuals (284.0 ± 6.5 kgm·min-1 and 8.5 ± 0.7 mml·l-1, respectively). Pre-exercise IGF-I was lower and FGF-2 was higher in the higher fit (335.0 ± 54.0 ng·ml-1 and 1.6 ± 0.1 ng·ml-1, respectively) compared with lower fit individuals (402.0 ± 50.0 ng·ml-1 and 1.4 ± 0.2 ng·ml-1, respectively). Following the anaerobic exercise, in both groups, FGF-2 decreased dramatically (p < 0.05); in the higher fit individuals FGF-2 level was 0.4 ± 0.1 pg·ml-1 compared to 0.1 ± 0.02 pg·ml-1 in the lower fit individuals. In contrast to FGF-2, IGF-I increased transiently to levels of 405.0 ± 62.0 ng·ml-1 in the higher fit individuals and to levels of 436 ± 57.0 ng·ml-1 in the lower fit individuals. However, the IGF-I elevation was significant (p < 0. 05) only in the higher fit individuals. In conclusion, the present study demonstrates that during aging, fitness level can alter circulating levels of IGF-I and FGF-2. Furthermore, fitness level can affect the response of both mediators to all-out anaerobic exercise.

Key words: Anaerobic exercise, aging, growth factors, hypertrophy, angiogenesis


           Key Points
  • The present study suggests that during aging, fitness level can alter circulating levels of IGF-I and FGF-2.
  • Furthermore, fitness level can affect the response of both mediators to all-out anaerobic exercise.
  • Anaerobic muscle activity is represented in many daily life activities of elderly individuals.
  • This may have clinical implications during aging, where the declined activity of growth factors is a major determinant of the loss of muscle strength and function.
 
 
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