Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2007) 06, 434 - 440

Research article
IGF-1 Gene Expression in Rat Colonic Mucosa After Different Exercise Volumes
Katja Buehlmeyer1, , Frank Doering2, Hannelore Daniel3, Anatoli Petridou4, Vassilis Mougios4, Thorsten Schulz1, Horst Michna1
Author Information
1 Institute of Public Health Research, Technical University Munich, Munich, Germany
2 Molecular Nutrition, Christian-Albrechts-University of Kiel, Kiel, Germany
3 Molecular Nutrition, Technical University Munich, Freising, Weihenstephan, Germany
4 Department of Physical Education and Sport Science, Aristoteles University of Thessaloniki, Thessaloniki, Greece

Katja Buehlmeyer
✉ Technical University Munich, Institute of Public Health Research, Connollystreet 32, 80809 Munich, Germany
Email: katjabuehlmeyer@gmx.net
Publish Date
Received: 12-03-2007
Accepted: 27-06-2007
Published (online): 01-12-2007
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ABSTRACT

The evidence is increasing for a close link between the insulin/insulin-like growth factor (IGF) system and colon cancer prevention by physical exercise. To reveal exercise-induced alterations in colon mucosa, gene expression of IGF-1 and related genes and serum IGF-1 were investigated. Twenty male Wistar rats performed a 12 week voluntary exercise program. Nine rats served as the control group. Gene expression of IGF-1, IGF-1 receptor (IGF-1R) and IGF-binding protein 3 (IGF-BP3) were quantified by real-time RT-PCR. Circulating IGF-1 was analyzed exercise volume-dependent. Based on 3 distinguished groups with low (L-EX, <2629 m·night-1), medium (M-EX, 3003-7458 m·night-1) and high exercise volume (H-EX, >8314 m·night-1), we observed lower serum IGF-1 levels (P < 0.05) in all exercise groups as compared to the control group and IGF-1 levels declined proportional to the increase in exercise volume. A significant (p < 0.05) positive correlation was found between IGF-1 concentration and body mass (r = 0.50) and a significant negative correlation exists between body mass and exercise volume (r = -0.50). Significant differences in colonic mRNA levels of IGF-1, IGF-1R and IGF-BP3 could not be observed. Based on our data we propose that the exercise as well as the body mass reduction leads to a decrease in circulating IGF-1 and this might represent a prime link to colon cancer prevention.

Key words: Cancer prevention, IGF-1R, IGF-BP3, real-time RT PCR, physical exercise


           Key Points
  • There were significantly lower serum IGF-1 levels in all exercise groups as compared to the control group.
  • GF-1 levels declined proportional to the increase in exercise volume.
  • A significant positive correlation was found between IGF-1 concentration and body mass and a significant negative correlation was found between body mass and exercise volume.
  • Significant differences in colonic mRNA levels of IGF-1, IGF-1R and IGF-BP3 could not be observed.
 
 
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