Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2009) 08, 219 - 224

Research article
Effects of Acute Moderate and Strenuous Exercise Bouts on IL-17 Production and Inflammatory Response in Trained Rats
Halil Duzova , Yunus Karakoc, Memet Hanifi Emre, Zumrut Yilmaz Dogan, Evren Kilinc
Author Information
Inonu University Faculty of Medicine, 44280 Malatya, Turkey

Halil Duzova
‚úČ Department of Physiology, Inonu University Faculty of Medicine, 44280 Malatya Turkey
Publish Date
Received: 23-01-2008
Accepted: 24-02-2009
Published (online): 01-06-2009
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In this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = - 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles.

Key words: Interleukin-17, cytokines, running, exercise, rat.

           Key Points
  • A single bout of acute strenuous running exercise markedly elevated IL-17 production.
  • This preliminary result should be supported by forthcoming studies that investigate the role of IL-17 in acute inflammatory process of skeletal muscle.
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