Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2009) 08, 271 - 277

Research article
A Common Variation in the Promoter Region of Interleukin-6 Gene Shows Association with Exercise Performance
Antti Huuskonen1, Minna Tanskanen2, Jani Lappalainen1, Niku Oksala1,3, Heikki Kyröläinen2, Mustafa Atalay1, 
Author Information
1 University of Kuopio, Finland
2 University of Jyväskylä, Finland
3 Tampere University Hospital, Finland

Mustafa Atalay
✉ Institute of Biomedicine, Physiology, University of Kuopio, POB 1627, FIN-70210 Kuopio, Finland Email:
Publish Date
Received: 24-02-2009
Accepted: 02-04-2009
Published (online): 01-06-2009
Share this article

Skeletal muscle-derived interleukin-6 (IL-6) is a pleiotropic cytokine which regulates body metabolism during strenuous physical exercise. OBJECTIVE: The effect of a potentially functional single nucleotide polymorphism (SNP) -174G/C of the IL6 gene (rs1800795) promoter was examined on maximal oxygen uptake (VO2max), body mass index (BMI) and plasma IL-6 levels in response to physical training. Fifty four male military conscripts were studied for 8 weeks during their basic training. At weeks 1, 5 and 8, VO2max and anthropometrics were measured, and blood samples collected before and after acute aerobic exercise. Acute exercise increased plasma IL-6 in subjects with genotype CG. Moreover, during the 8-week training period, a tendency for increased plasma IL-6 was observed in subjects with this genotype. VO2max values increased in all genotype groups, but subjects with genotype CG made the greatest gains in VO2max. Training significantly decreased BMI only in subjects with genotype CG. Our findings suggest that the allele C may have an effect on plasma IL-6 response to acute exercise in healthy male subjects. Exercise training has a favourable effect on VO2max and BMI, with the most prominent effects in subjects with genotype CG. Thus we conclude that this SNP may account for individual response to exercise training.

Key words: Maximal oxygen uptake, IL-6, polymorphism, body mass index, training.

           Key Points
  • Allele C of the IL6 promoter SNP -174G/C may have an effect on plasma IL-6 response to acute exercise.
  • All subjects responded to physical exercise, but the improvement in VOmax and decrease in BMI after training are more pronounced in the individuals with genotype CG, hence the IL6 promoter SNP -174G/C may have an influence on training responses.
  • The small number of subjects investigated in the present study warrants further research to confirm these findings in large cohorts.
Home Issues About Authors
Contact Current Editorial board Authors instructions
Email alerts In Press Mission For Reviewers
Archive Scope
Supplements Statistics
Most Read Articles
  Most Cited Articles
JSSM | Copyright 2001-2020 | All rights reserved. | LEGAL NOTICES | Publisher

It is forbidden the total or partial reproduction of this web site and the published materials, the treatment of its database, any kind of transition and for any means, either electronic, mechanic or other methods, without the previous written permission of the JSSM.

This work is licensed under a Creative Commons License Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.