Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2009) 08, 51 - 57

Research article
Effects of voluntary wheel running on satellite cells in the rat plantaris muscle
Mitsutoshi Kurosaka1, Hisashi Naito1, , Yuji Ogura1,2, Atsushi Kojima2, Katsumasa Goto2,3, Shizuo Katamoto1
Author Information
1 Department of Exercise Physiology, Graduate School of Health and Sports Science, Juntendo University, Chiba, apan
2 Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Japan
3 Laboratory of Physiology, Toyohashi SOZO University, Toyohashi, Japan

Hisashi Naito
‚úČ Department of Exercise Physiology, Graduate School of Health and Sports Science, Juntendo University, Chiba, 270-1695, Japan
Email: naitoh@sakura.juntendo.ac.jp
Publish Date
Received: 13-11-2008
Accepted: 03-12-2008
Published (online): 01-03-2009
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ABSTRACT

This study investigated the effects of voluntary wheel running on satellite cells in the rat plantaris muscle. Seventeen 5-week-old male Wistar rats were assigned to a control (n = 5) or training (n = 12) group. Each rat in the training group ran voluntarily in a running-wheel cage for 8 weeks. After the training period, the animals were anesthetized, and the plantaris muscles were removed, weighed, and analyzed immunohistochemically and biochemically. Although there were no significant differences in muscle weight or fiber area between the groups, the numbers of satellite cells and myonuclei per muscle fiber, percentage of satellite cells, and citrate synthase activity were significantly higher in the training group compared with the control group (p < 0.05). The percentage of satellite cells was also positively correlated with distance run in the training group (r = 0.61, p < 0.05). Voluntary running can induce an increase in the number of satellite cells without changing the mean fiber area in the rat plantaris muscle; this increase in satellite cell content is a function of distance run.

Key words: Endurance training, muscle damage, hypertrophy, myonuclear, Pax7.


           Key Points
  • There is no study about the effect of voluntary running on satellite cells in the rat plantaris muscle.
  • Voluntary running training causes an increase of citrate synthase activity in the rat plantaris muscle but does not affect muscle weight and mean fiber area in the rat plantaris muscle.
  • Voluntary running can induce an increase in the number of satellite cells without hypertrophy of the rat plantaris muscle.
 
 
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