Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2009) 08, 67 - 76

Research article
Serum IGF-I and hormonal responses to incremental exercise in athletes with and without left ventricular hypertrophy
Aleksandra Żebrowska1, , Zbigniew Gąsior2, Józef Langfort1,3
Author Information
1 Department of Physiology, Academy of Physical Education, Katowice, Poland
2 Department of Cardiology, Silesian University School of Medicine, Katowice, Poland
3 Laboratory of Experimental Pharmacology, Polish Academy of Science, Warsaw, Poland

Aleksandra Żebrowska
✉ Department of Physiology, Academy of Physical Education, Mikołowska st. 72A, 40-065 Katowice, Poland
Email: olazebrowska@yahoo.com
Publish Date
Received: 06-10-2008
Accepted: 23-12-2008
Published (online): 01-03-2009
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ABSTRACT

We investigated the response of insulin-like growth factor (IGF- I), insulin-like growth factor binding protein-3 (IGFBP-3) and some hormones, i.e., testosterone (T), growth hormone (GH), cortisol (C), and insulin (I), to maximal exercise in road cyclists with and without diagnosed left ventricular hypertrophy. M-mode and two-dimensional Doppler echocardiography was performed in 30 professional male endurance athletes and a group of 14 healthy untrained subjects using a Hewlett-Packard Image Point HX ultrasound system with standard imaging transducers. Echocardiography and an incremental physical exercise test were performed during the competitive season. Venous blood samples were drawn before and immediately after the maximal cycling exercise test for determination of somatomedin and hormonal concentrations. The basal concentration of IGF-I was statistically higher (p < 0.05) in athletes with left ventricular muscle hypertrophy (LVH) when compared to athletes with a normal upper limit of the left ventricular wall (LVN) (p < 0.05) and to the control group (CG) (p < 0.01). The IGF-I level increased significantly at maximal intensity of incremental exercise in CG (p < 0.01), LVN (p < 0.05) and LVH (p < 0.05) compared to respective values at rest. Long-term endurance training induced an increase in resting (p < 0.01) and post-exercise (p < 0.05) IGF-I/IGFBP-3 ratio in athletes with LVH compared to LVN. The testosterone (T) level was lower in LVH at rest compared to LVN and CG groups (p < 0.05). These results indicate that resting serum IGF-I concentration were higher in trained subjects with LVH compared to athletes without LVH. Serum IGF- I/IGFBP-3 elevation at rest and after exercise might suggest that IGF-I act as a potent stimulant of left ventricular hypertrophy in chronically trained endurance athletes.

Key words: Echocardiography, heart, somatomedins, anabolic hormones, endurance training.


           Key Points
  • In sports training athletes engaged in the same training regimen acquired different stages of cardiac hypertrophy.
  • Physical exercise had a significant effect on serum insulin-like growth factor - I concentration depending on maximal oxygen uptake during endurance exercise.
  • Athletes with clinically diagnosed physiological left ventricular hypertrophy had higher resting serum insulin-like growth factor - I concentration compared to those without left ventricular hypertrophy and sedentary subjects.
  • Increased insulin-like growth factor - I release during long-term training seems to significantly contribute to sports-specific functional adaptation of the left ventricle.
 
 
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