Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2011) 10, 45 - 51

Research article
Functional Status and Inflammation after Preseason Training Program in Professional and Recreational Soccer Players: a Proteomic Approach
Francisco J. Martín-Sánchez2, José María Villalón3, José J. Zamorano-León1, Luis Fernández Rosas3, Ricardo Proietti1, Petra J. Mateos-Caceres1, Juan J. González-Armengol2, Pedro Villarroel2, Carlos Macaya1, Antonio J. López-Farré1, 
Author Information
1 Cardiovascular Research Unit, Cardiology Department,
2 Emergency Unit, Hospital Clínico San Carlos,
3 Medical Department of Atlético de Madrid Football Club, Madrid, Spain

Antonio J. López-Farré
✉ Cardiovascular Research Unit, Hospital Clínico San Carlos, C/ Profesor Martín Lagos s/n. Madrid 28040, Spain
Publish Date
Received: 18-03-2010
Accepted: 27-10-2010
Published (online): 01-03-2011
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The purpose of the study was to determine if an intensive pre- season training program modifies the inflammatory status in professional soccer players and if this inflammatory profile may be associated with the physical state. We compared plasma protein biomarkers, using proteomics, and the physiological state and cardiac function in 12 professional soccer players and 9 recreational soccer players. Reduced cardiac low frequency [LF] after the pre- season training program previous competition with respect to recreational soccer players was found. No differences were found in cardiac high frequency, cardiac high frequency/low frequency ratio, tension index and oxygen volume consumption. Alpha-1-antitrypsin isotype-3, fibrinogen-gamma isotypes-1, 2 and 3 and vitamin-D-binding protein isotype-1 were reduced in professionals players compared with those in recreational players. However, an increased content of alpha-1-antitrypsin isotype-6 and alpha-1-antichymotrypsin 1 and 4 were found in professional soccer players. Spearman’s analysis showed a positive correlation between LF and fibrinogen-gamma chain isotype 3; but LF was negatively correlated with alpha-antichymotrypsin isotype 4. Professional soccer players submitted to an intensive training showed differences in the content of plasma proteins associated with inflammatory/oxidative stress and thrombosis with respect to recreational soccer players. Proteomics analysis in combination with the analysis of cardiac function assessment may be useful to know more in depth molecular processes associated with sport and intensive exercise.

Key words: Inflammation, proteomics, soccer, physical performance

           Key Points
  • Proteomics allow us to find differences in the plasma protein content in sportsmen.
  • Just after pre-season training program, professional soccer players showed lower content of circulating proteins associated with inflammation compared to recreational soccer players.
  • Proteomic analysis in combination with the analysis of cardiac function may be useful to know more in depth molecular inflammatory and oxidative processes associated with the sport.
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