Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
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©Journal of Sports Science and Medicine (2011) 10, 93 - 96

Research article
The Effect of Regular Exercise on Development of Sarcoma Tumor and Oxidative Damage in Mice Liver
Maria Sasvari1, Albert W. Taylor2, Dezso Gaal3, Zsolt Radak1, 
Author Information
1 Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis University Budapest, Hun-gary
2 School of Kinesiology, Faculty of Health Sciences and Department Physiology, Faculty of Medicine and Den-tistry, University of Western Ontario, London, Canada
3 National Institute of Oncology, Budapest, Hungary

Zsolt Radak
‚úČ Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis Univ. TF, Alkotas u. 44, Budapest, Hungary
Email: radak@mail.hupe.hu
Publish Date
Received: 31-03-2010
Accepted: 09-11-2010
Published (online): 01-03-2011
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ABSTRACT

Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor.

Key words: Exercise, cancer, oxidative stress, DNA damage, reactive carbonyl derivatives


           Key Points
  • Regular exercise has a capability to reduce the inci-dence and progress of certain cancers.
  • Free radicals could act as a promoters and suppres-sors of cancers.
  • Exercise can suppress the development of Sarcoma, but the underlying mechanisms are not known.
 
 
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