Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2012) 11, 387 - 392

Research article
Effects of a Combined Aerobic and Strength Training Program in Youth Patients with Acute Lymphoblastic Leukemia
Maria Beatriz Perondi1, , Bruno Gualano1,2, Guilherme Gianini Artioli2, Vítor de Salles Painelli1, Vicente Odone Filho1, Gabrieli Netto1, Mavi Muratt1, Hamilton Roschel1,2, Ana Lúcia de Sá Pinto1
Author Information
1 School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
2 School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil

Maria Beatriz Perondi
✉ University of Sao Paulo, School of Medicine. Av. Dr. Arnaldo, 455, Sao Paulo, SP Brazil
Publish Date
Received: 22-12-2011
Accepted: 04-05-2012
Published (online): 01-09-2012
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Cure rates of youth with Acute Lymphoblastic Leukemia (ALL) have increased in the past decades, but survivor’s quality of life and physical fitness has become a growing concern. Although previous reports showed that resistance training is feasible and effective, we hypothesized that a more intense exercise program would also be feasible, but more beneficial than low- to moderate-intensity training programs. We aimed to examine the effects of an exercise program combining high-intensity resistance exercises and moderate-intensity aerobic exercises in young patients undergoing treatment for ALL. A quasi-experimental study was conducted. The patients (n = 6; 5-16 years of age) underwent a 12-week intra-hospital training program involving high-intensity strength exercises and aerobic exercise at 70% of the peak oxygen consumption. At baseline and after 12 weeks, we assessed sub-maximal strength (10 repetition-maximum), quality of life and possible adverse effects. A significant improvement was observed in the sub maximal strength for bench press (71%), lat pull down (50%), leg press (73%) and leg extension (64%) as a result of the training (p < 0.01). The parents’ evaluations of their children’s quality of life revealed an improvement in fatigue and general quality of life, but the children’s self-reported quality of life was not changed. No adverse effects occurred. A 12-week in-hospital training program including high-intensity resistance exercises promotes marked strength improvements in patients during the maintenance phase of the treatment for Acute Lymphoblastic Leukemia without side-effects. Parents’ evaluations of their children revealed an improvement in the quality of life.

Key words: Acute lymphoblastic leukemia, child, strength training, pediatrics, quality of life

           Key Points
  • Patients with ALL present low muscle strength and poor quality of life.
  • High-intensity resistance exercises combined with moderate-intensity aerobic exercise improved muscle strength and quality of life during the maintenance phase of ALL treatment.
  • The exercise training program seemed to be tolerable and safe in ALL patients.
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