Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
from September 2014
©Journal of Sports Science and Medicine (2012) 11, 551 - 556

Research article
Does Single Intramuscular Application of Autologous Conditioned Plasma Influence Systemic Circulating Growth Factors?
Gert Schippinger1, 2, , Florian Fankhauser2, Karl Oettl3, Stefan Spirk1, 4, Peter Hofmann1, 4
Author Information
1 Human Performance Research, University of Graz and Medical University of Graz,
2 Sportchirurgie Plus Graz,
3 Institute of Physiological Chemistry, Medical University of Graz,
4 Institute of Sports Science, University of Graz, Austria

Gert Schippinger
✉ Human Performance Research Graz, University of Graz and Medical University of Graz, Max-Mell-Allee 11, A-8010 Graz, Austria
Publish Date
Received: 22-04-2012
Accepted: 04-05-2012
Published (online): 01-09-2012
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Platelet-rich plasma (PRP) has been employed to treat sports injuries to possibly accelerate healing and regeneration. This method offers some potential, especially for athletes. Growth factors are generally prohibited by the World Anti Doping Agency with exception to PRP which may induce adverse effects. The aim of this study was to evaluate any systemic increase of growth factors such as Insulin Like Growth Factor-1, Endothelial Growth Factors, Platelet-Derived Growth Factors, Fibroblast Growth Factors, Vascular-Endothelial Growth Factor and Transforming Growth Factors after local intramuscular administration of PRP in young, healthy male subjects keeping in mind adverse treatment effects. Enriched plasma from centrifuged blood samples was injected into the gluteus muscle. Venous blood was collected and serum prepared before as well as 0.5, 3 and 24 hours after PRP administration. Growth factors were analyzed using ELISA test kits. No significant systemic increase of growth factor levels was found after PRP injection except TGF-β2. For that reason the PRP method may be applied for muscle injury treatment in elite athletes although further studies are necessary to clarify the response to the unspecific increased TGF-β2 blood levels, which could increase the risk for local fibrosis.

Key words: Autologous Conditioned Plasma, blood levels of growth factors, doping, platelet-rich plasma.

           Key Points
  • Muscle injury
  • Autologous conditioned plasma
  • Systemic circulating growth factors
  • Doping
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