Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
Views
6258
Download
150
from September 2014
 
©Journal of Sports Science and Medicine (2012) 11, 719 - 726

Research article
Effects of Prolonged Endurance Exercise on Vascular Endothelial and Inflammation Markers
Haemi Jee1,2, Youngsoo Jin1,2, 
Author Information
1 Department of Medical Science, University of Ulsan College of Medicine, Seoul, Korea
2 Sport Health Medicine Center, Asan Medical Center, Seoul, Korea.

Youngsoo Jin
✉ Department of Medical Science, University of Ulsan College of Medicine, and Sport Health Medicine Center, Asan Medical Center 86, Asanbyeongwon-gil, Songpa-gu, Seoul, 138-736, Korea
Email: ysjin@amc.seoul.kr
Publish Date
Received: 16-07-2012
Accepted: 03-10-2012
Published (online): 01-12-2012
Share this article
 
 
ABSTRACT

Systemic inflammation has been found in association with vascular endothelial function for clinical implications including exercise-induced pathology. However, information on the relationship between the exercise-related inflammatory responses and endothelial function is limited. This study aimed to investigate the effects of prolonged endurance exercise on the expression of selected soluble adhesion molecules and inflammatory markers. Twenty-four middle-aged males participating in a 308 km ultra-marathon were recruited in this study. Venous blood was collected at baseline, 100 km, 200 km, and 308 km for the analysis of sVCAM-1, sE-selectin, leukocytes, hs-CRP, CK, and TNF-α. Significant increases of sVCAM-1, sE-selectin, and leukocytes were observed at 100 km. sVCAM-1 had the greatest significant increase at 100 km. In addition, sVCAM-1 was significantly associated with the running speed and leukocytes. sE-selectin was significantly associated with leukocytes, hs-CRP, TNF-α, and CK. Delayed rises in hs-CRP and CK were observed at 200 km. TNF-α fluctuated throughout the race with a significant increase at 308 km. Delayed onset of hs-CRP and continuously increased sE-selectin suggest anti-inflammatory responses to suppress pro-inflammatory markers such as TNF-α. Prolonged repetition of muscle contraction may have released delayed CK and significant rise in TNF-α toward the end of the race. The present study demonstrated an activation of the surrogate markers of endothelial dysfunction in relationship to exercise intensity and leukocyte trafficking without a significant activation of the inflammatory responses. Thus, alteration of the endothelium may be related to increased blood flow and shear stress put upon the endothelium in response to increased oxygen demand on the heart.

Key words: Endothelial function, inflammation, leukocytes, vascular adhesion molecules, ultra-marathon


           Key Points
  • Systemic inflammation is associated with vascular endothelial function for clinical implications including exercise-induced pathology.
  • Inflammatory process involves a cascade of inflammatory and endothelial markers.
  • A prolonged endurance ultra-marathon induced significant increases in systemic inflammation and vascular endothelial markers at different checkpoints.
  • sVCAM-1, a surrogate marker of endothelial dysfunction, significantly increased in response to increased exercise intensity and leukocyte trafficking without significant changes in the inflammatory markers.
  • Prolonged repetition of muscle contraction may have delayed released of pro-inflammatory markers, CK, hs-CRP, and TNF-α.
 
 
Home Issues About Authors
Contact Current Editorial board Authors instructions
Email alerts In Press Mission For Reviewers
Archive Scope
Supplements Statistics
Most Read Articles
  Most Cited Articles
 
  
 
JSSM | Copyright 2001-2020 | All rights reserved. | LEGAL NOTICES | Publisher

It is forbidden the total or partial reproduction of this web site and the published materials, the treatment of its database, any kind of transition and for any means, either electronic, mechanic or other methods, without the previous written permission of the JSSM.

This work is licensed under a Creative Commons License Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.