Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
©Journal of Sports Science and Medicine (2015) 14, 91 - 97

Research article
Acute Pro- and Anti-Inflammatory Responses to Resistance Exercise in Patients with Coronary Artery Disease: A Pilot Study
Konstantinos A. Volaklis1,2,3, , Ilias Smilios1, Apostolos T. Spassis1, Christos E. Zois1, Helen T. Douda1, Martin Halle2,4, Savvas P. Tokmakidis1
Author Information
1 Democritus University of Thrace Department of Physical Education & Sports Science, Komotini, Greece
2 Department of Prevention and Sports Medicine, Technische Universitaet Muenchen, Munich, Germany
3 7FIT, Ambulantes Herz-Rehazentrum, Augsburg, Germany
4 Munich Heart Alliance, Munich Germany

Konstantinos A. Volaklis
✉Democritus University of Thrace, Department of Physical Education & Sports Science, University Campus, 69100 Komotini, Greece
Publish Date
Received: 29-07-2014
Accepted: 07-10-2014
Published (online): 01-03-2015
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Little is known about the inflammatory effects of resistance exercise in healthy and even less in diseased individuals such as cardiac patients. The purpose of this study was to examine the acute pro- and anti-inflammatory responses during resistance exercise (RE) in patients with coronary artery disease. Eight low risk patients completed two acute RE protocols at low (50% of 1 RM; 2x18 rps) and moderate intensity (75% of 1 RM; 3x8 rps) in random order. Both protocols included six exercises and had the same total load volume. Blood samples were obtained before, immediately after and 60 minutes after each protocol for the determination of lactate, TNFα, INF-γ, IL-6, IL-10, TGF-β1, and hsCRP concentrations. IL-6 and IL-10 levels increased (p < 0.05) immediately after both RE protocols with no differences between protocols. INF-γ was significantly lower (p < 0.05) 60 min after the low intensity protocol, whereas TGF-β1 increased (p < 0.05) immediately after the low intensity protocol. There were no differences in TNF-& and hs-CRP after both RE protocols or between protocols. The above data indicate that acute resistance exercise performed at low to moderate intensity in low risk, trained CAD patients is safe and does not exacerbate the inflammation associated with their disease.

Key words: Resistance exercise, inflammation, cardiac rehabilitation

           Key Points
  • Acute resistance exercise is safe without exacerbating inflammation in patients with CAD.
  • Both exercise intensities (50 and 75% of 1 RM) elicit desirable pro-and anti-inflammatory responses.
  • With both exercise intensities (50 and 75% of 1 RM) acceptable clinical hemodynamic alterations were observed.
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