Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
ISSN: 1303 - 2968   
Ios-APP Journal of Sports Science and Medicine
Androit-APP Journal of Sports Science and Medicine
©Journal of Sports Science and Medicine (2016) 15, 196 - 203

Research article
Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training
Ragip Pala1, Cemal Orhan2, Mehmet Tuzcu3, Nurhan Sahin2, Shakir Ali4, Vedat Cinar1, Mustafa Atalay5, Kazim Sahin1, 
Author Information
1 Department of Movement and Training Science, Faculty of Sports Sciences, Firat University, Elazig, Turkey
2 Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
3 Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
4 Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India
5 Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland

Kazim Sahin
✉ DVM, Ph.D., F.A.C.N., Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig 23119, Turkey.
Publish Date
Received: 27-08-2015
Accepted: 11-01-2016
Published (online): 23-02-2016
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This study reports the effects of Q10, coenzyme Q10 or ubiquinone, a component of the electron transport chain in mitochondria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), inhibitors of kappa B (IκB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase 1 (HO-1) in rats after chronic exercise training for 6 weeks. 8-week old male Wistar rats were assigned randomly to one of four treatments planned in a 2 x 2 factorial arrangement of two condition (sedentary vs. exercise training), and two coenzyme Q10 levels (0 and 300 mg/kg per day for 6 weeks). The expression levels of the target proteins were determined in the heart, liver and muscle, and biochemical parameters including creatinine, urea, glucose and lipid profile were investigated in plasma. When compared with sedentary group, significant decreases in heart, liver and muscle NFκB levels by 45%, 26% and 44% were observed in Q10 supplemented rats after exercise training, respectively, while the inhibitory protein IκB increased by 179%, 111% and 127% in heart, liver and muscle tissues. Q10 supplementation caused an increase in Nrf2 (167%, 165% and 90%) and HO-1 (107%, 156% and 114%) after exercise training in heart, liver and muscle tissues (p < 0.05). No significant change was observed in any of the parameters associated with protein, carbohydrate and lipid metabolism, except that exercise caused a decrease in plasma triglyceride, which was further decreased by Q10. In conclusion, these results suggest that Q10 modulates the expression of NFκB, IκB, Nrf2 and HO-1 in exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense.

Key words: Coenzyme Q10, exercise, signaling pathway

           Key Points
  • Coenzyme Q10 is a component of the electron transport chain in mitochondria which is linked to the generation of energy in the cell.
  • Coenzyme Q10 may inhibit the peroxidation of lipids, thus acting as an antioxidant and protects tissue against oxidative injury.
  • Using of coenzyme Q10 can significantly elevate IκB, Nrf2 and HO-1 and reduce NFκB during exercise training.
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